Thrombopoietin Receptor

By Targets:	Thrombopoietin Receptor (12) Apoptosis (3) Bacterial (3) Cyclin G-associated Kinase (GAK) (1) Isotope-Labeled Compounds (2) JAK (1) p38 MAPK (1) STAT (1)
By Research Areas:	Cancer (4) Cardiovascular Disease (7) Infection (3) Inflammation/Immunology (6)

Targets Recommended: Thrombopoietin Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-122620

Hetrombopag	Thrombopoietin Receptor	Inflammation/Immunology Cancer
Hetrombopag is a potent **thrombopoietin receptor** agonist. Hetrombopag is efficacious and well tolerated with a manageable safety profile. Hetrombopag has the potential for the research of immune thrombocytopenia .

HY-19883

Lusutrombopag 1 Publications Verification S-888711	Thrombopoietin Receptor	Inflammation/Immunology
Lusutrombopag is an orally bioavailable **thrombopoietin (TPO) receptor** agonist, used for treatment of chronic liver disease.

HY-125101A

Rafutrombopag diolamine	Thrombopoietin Receptor	Cardiovascular Disease
Rafutrombopag diolamine is the derivative of Rafutrombopag. Rafutrombopag is a thrombopoietin receptor agonist .

HY-19883S

Lusutrombopag-d13 S-888711-d₁₃	Isotope-Labeled Compounds Thrombopoietin Receptor	Inflammation/Immunology
Lusutrombopag-d₁₃ is deuterium labeled Lusutrombopag. Lusutrombopag is an orally bioavailable thrombopoietin (TPO) receptor agonist, used for treatment of chronic liver disease.

HY-153239

Eltrombopag methyl ester	Thrombopoietin Receptor	Inflammation/Immunology
Eltrombopag methyl ester is a derivative of Eltrombopag, which is a **thrombopoietin (Tpo) receptor** agonist, which can promote platelet production and is used in research related to specific types of thrombocytopenia .

HY-148748

Butyzamide	JAK STAT p38 MAPK	Others
Butyzamide is an orally active activator of Mpl, a thrombopoietin (TPO) receptor. Butyzamide increases the phosphorylation level of JAK2, STAT3, STAT5 and MAPK. Butyzamide increases the level of human platelets in mouse xenotransplantation assay .

HY-112486

TA-316 Megakaryocytes/platelets inducing agent	Cyclin G-associated Kinase (GAK)	Cardiovascular Disease
TA-3166 (Megakaryocytes/platelets inducing agent) is a novel chemically synthesized c-MPL agonist (CMA) and **thrombopoietin (TPO) receptor** agonist. TA-316 enhances ex vivo platelet generation from human-induced pluripotent stem (iPS) cells .

HY-13463B

Avatrombopag hydrochloride 3 Publications Verification AKR-501 hydrochloride; E5501 hydrochloride; YM477 hydrochloride	Thrombopoietin Receptor	Cardiovascular Disease
Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide **thrombopoietin (TPO) receptor agonist (EC₅₀**=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag hydrochloride is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A .

HY-13463

Avatrombopag 3 Publications Verification AKR-501; E5501; YM477	Thrombopoietin Receptor	Inflammation/Immunology
Avatrombopag (AKR-501) is an orally active, nonpeptide **thrombopoietin (TPO) receptor agonist (EC₅₀**=3.3 nM). Avatrombopag mimics the biological activities of TPO. Avatrombopag increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A .

HY-13463A

Avatrombopag maleate AKR-501 maleate; E5501 maleate; YM477 maleate	Thrombopoietin Receptor	Inflammation/Immunology
Avatrombopag maleate (AKR-501) is an orally active, nonpeptide **thrombopoietin (TPO) receptor agonist (EC₅₀**=3.3 nM). Avatrombopag maleate mimics the biological activities of TPO. Avatrombopag maleate increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag maleate is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A .

HY-15306

Eltrombopag Maximum Cited Publications 10 Publications Verification SB-497115	Thrombopoietin Receptor Bacterial Apoptosis	Infection Cardiovascular Disease Cancer
Eltrombopag (SB-497115) is an orally active **thrombopoietin receptor** nonpeptide agonist. Eltrombopag owns thrombopoietic activity, and has been used to research low blood platelet counts with chronic immune thrombocytopenia. Eltrombopag can be used for the research of cardiovascular. Eltrombopag also has highly inhibitory effects against multidrug resistant Staphylococcus aureus. Eltrombopag can induce apoptosis in hepatocellular carcinomab (HCC) as well .

HY-15306A

Eltrombopag Olamine Maximum Cited Publications 10 Publications Verification Eltrombopag diethanolamine salt; SB-497115GR	Thrombopoietin Receptor Bacterial Apoptosis	Infection Cardiovascular Disease Cancer
Eltrombopag Olamine (Eltrombopag diethanolamine salt) is an orally active **thrombopoietin receptor** nonpeptide agonist. Eltrombopag Olamine owns thrombopoietic activity, and has been used to research low blood platelet counts with chronic immune thrombocytopenia. Eltrombopag Olamine can be used for the research of cardiovascular. Eltrombopag Olamine also has highly inhibitory effects against multidrug resistant Staphylococcus aureus. Eltrombopag Olamine can induce apoptosis in hepatocellular carcinomab (HCC) as well .

HY-15306S

Eltrombopag-13C4 1 Publications Verification SB-497115-¹³C₄	Thrombopoietin Receptor Bacterial Apoptosis	Infection Cardiovascular Disease Cancer
Eltrombopag- ¹³C₄ (SB-497115- ¹³C₄) is ^{13 sup>C-labeled Z-Eltrombopag. Z-Eltrombopag is an orally active thrombopoietin-receptor non-peptide agonist with platelet-stimulating activity for the study of chronic immune thrombocytopenia. Eltrombopag also has strong inhibitory effects on multidrug-resistant Staphylococcus aureus (Staphylococcus aureus) and can induce apoptosis (apoptosis) in liver cancer cells .}

HY-13463BS

Avatrombopag-d8 hydrochloride AKR-501-d₈ hydrochloride; E5501-d₈ hydrochloride; YM477-d₈ hydrochloride	Isotope-Labeled Compounds Thrombopoietin Receptor	Cardiovascular Disease
Avatrombopag-d₈ (hydrochloride) is deuterium labeled Avatrombopag (hydrochloride). Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC50=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag hydrochloride is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A[1][2][3].

Species:	Rat (2)
Tag:	His (1) Fc (1)
Source:	HEK293 (1) Sf9 insect cells (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P74244

	C-MPL Protein, Rat (HEK293, Fc) CD110; c-Mpl; MPL; MPLV; Thrombopoietin R; TPO-R	Rat	HEK293
	The C-MPL Protein, a receptor for thrombopoietin, is a protein encoded in humans by the oncogene of myeloproliferative leukemia virus. The C-MPL Protein is involved in the activation of the JAK/STAT/MAPK signaling pathway. C-MPL Protein is a biomarker for thrombocytopenia. C-MPL Protein, Rat (HEK293, Fc) is the recombinant rat-derived C-MPL protein, expressed by HEK293 , with C-hFc labeled tag. The total length of C-MPL Protein, Rat (HEK293, Fc) is 479 a.a., with molecular weight of ~80.7 kDa.

HY-P74243

	C-MPL Protein, Rat (sf9, His) CD110; c-Mpl; MPL; MPLV; Thrombopoietin R; TPO-R	Rat	Sf9 insect cells
	The C-MPL Protein, a receptor for thrombopoietin, is a protein encoded in humans by the oncogene of myeloproliferative leukemia virus. The C-MPL Protein is involved in the activation of the JAK/STAT/MAPK signaling pathway. C-MPL Protein is a biomarker for thrombocytopenia. C-MPL Protein, Rat (sf9, His) is the recombinant rat-derived C-MPL protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of C-MPL Protein, Rat (sf9, His) is 500 a.a., with molecular weight of ~55 kDa.


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Cat. No.	Product Name	Chemical Structure

HY-15306S

Eltrombopag-13C4 1 Publications Verification
Eltrombopag- ¹³C₄ (SB-497115- ¹³C₄) is ^{13 sup>C-labeled Z-Eltrombopag. Z-Eltrombopag is an orally active thrombopoietin-receptor non-peptide agonist with platelet-stimulating activity for the study of chronic immune thrombocytopenia. Eltrombopag also has strong inhibitory effects on multidrug-resistant Staphylococcus aureus (Staphylococcus aureus) and can induce apoptosis (apoptosis) in liver cancer cells .}

Eltrombopag-13C4

1 Publications Verification

Eltrombopag- ¹³C₄ (SB-497115- ¹³C₄) is ^{13 sup>C-labeled Z-Eltrombopag. Z-Eltrombopag is an orally active thrombopoietin-receptor non-peptide agonist with platelet-stimulating activity for the study of chronic immune thrombocytopenia. Eltrombopag also has strong inhibitory effects on multidrug-resistant Staphylococcus aureus (Staphylococcus aureus) and can induce apoptosis (apoptosis) in liver cancer cells .}

HY-19883S

Lusutrombopag-d13
Lusutrombopag-d₁₃ is deuterium labeled Lusutrombopag. Lusutrombopag is an orally bioavailable thrombopoietin (TPO) receptor agonist, used for treatment of chronic liver disease.

HY-13463BS

Avatrombopag-d8 hydrochloride
Avatrombopag-d₈ (hydrochloride) is deuterium labeled Avatrombopag (hydrochloride). Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC50=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag hydrochloride is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A[1][2][3].

Avatrombopag-d8 hydrochloride

Avatrombopag-d₈ (hydrochloride) is deuterium labeled Avatrombopag (hydrochloride). Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC50=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag hydrochloride is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A[1][2][3].

Cat. No.	Product Name	Application	Reactivity

HY-P82496

Thrombopoietin Receptor Antibody (YA2241)

MPL; TPOR; Thrombopoietin Receptor; TPO-R; Myeloproliferative leukemia protein; Proto-oncogene c-Mpl; CD110
WB Human, Mouse, Rat

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
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